Synthesis and anticancer activities of diquinazoline diselenides compounds

Abstract

A series of novel diquinazoline diselenide compounds was designed and synthesized with substituted 4-chloroquinazoline and sodium diselenide. Their structures were confirmed by IR, 1H NMR, 13C NMR, and elemental analyses.The antitumor activity of the new compounds was evaluated by MTT method. Compound 1a, 1c, 1h and 1i were found to have activities against MDA-MB-435, A549,MDA-MB-231, SiHa, and HeLa cells. Moreover, compared with the commercial anticancer drugs Gefitinib, Oxaliplatin,Taxol, 10-Hydroxycamptothec in, and Epirubicin Hydrochloride,1a exerted better antitumor effects on corresponding cell lines at 10 μM.