Microwave induced synthesis, characterization and antitumor activities of some bis-(3,5-diaryl-2-pyrazolin1-yl)methanes
Vol. 66 No. 542 (2009), Articles
Vol. 66 No. 542 (2009)

Microwave induced synthesis, characterization and antitumor activities of some bis-(3,5-diaryl-2-pyrazolin1-yl)methanes

Articles
Birbal Bajia
Synthetic Chemistry Laboratory Department of Chemistry Maharanapratap Postgraduate Govt. College Chittorgarh-312001 (Raj.)
Ravindra Kumar
Synthetic Chemistry Laboratory Department of Chemistry Maharanapratap Postgraduate Govt. College Chittorgarh-312001 (Raj.)
K. Srivastava
Synthetic Chemistry Laboratory Department of Chemistry Maharanapratap Postgraduate Govt. College Chittorgarh-312001 (Raj.)
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Bajia, Birbal et al. “Microwave induced synthesis, characterization and antitumor activities of some bis-(3,5-diaryl-2-pyrazolin1-yl)methanes”. Afinidad. Journal of Chemical Engineering Theoretical and Applied Chemistry, vol.VOL 66, no. 542, https://raco.cat/index.php/afinidad/article/view/277704.


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Abstract

(3,5yl)methanes were prepared by condensation of 3,5-diaryl-2-pyrazolines with formaldehyde
under microwave irradiation condition. Antitumor activity of synthesized compounds was evaluated by estimating the effect of these compounds on the growth of cells. Breast adenocarcinoma (MCF-7), mammary cancer (EVSA-7) and gastrointestinal cell lines (HepG-2) were used. Four compounds have shown inhibition for HepG-2 cancer growth, three compounds were active against
EVSA-7 cancer cells.

Keywords

  • Microwave irradiation
  • pyrazolines
  • antitumor activity
  • mammary cancer
  • gastrointestinal cell lines.
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