Anti-Alzheimer and Anti-cox2 Activities of the Newly Synthesized 2,3’-Bipyridine Derivatives (I)

Abstract

3-Aryl-1-pyridin-3-ylprop-2-en-1-ones 1a,b reacted with
2-cyanoethanethioamide (2) to afford the corresponding
4-aryl-6-thioxo-1,6-dihydro-2,3’-bipyridine-5-carbonitriles
6a,b. The synthetic potentiality of compounds 6a,b was
investigated in the present study via their reactions with
several active-hydrogen containing compounds 8a-g aiming
to synthesize 4-aryl-6-pyridin-3-ylthieno[2,3-b]pyridin-
3-amines 10a-n via 6-(alkylthio)-4-aryl-2,3’-bipyridine-5-
carbonitriles 9a-n. The structures of all newly synthesized
heterocyclic compounds were elucidated by considering the data of IR, 1H NMR, mass spectra as well as that of elemental
analyses. Anti-Alzheimer and anti-cox2 activities for all newly synthesized heterocyclic compounds were investigated.