Gender Differences in Cognition and Social Cognition in Patients Affected by Psychosis in the Process of Psychosocial Rehabilitation

Objectives: The objectives of our study were to explore gender differences in Cognition and Social Cognition in patients affected by Psychosis in process of psychosocial rehabilitation and to establish a model of the relationship between Psychopathology, Cognition and Social Cognition in function of the gender, and attending to relevant clinical, sociodemographics and outcome factors.

Methodology: Cross-sectional observational study with 124 Non-Affective Schizophrenia Spectrum patients included consecutively in Community Rehabilitation Program at XXXXXXXXXXXXXXX (XXXXX, XXXXXXXXX), assessed through PANSS (using Wallwork's factors) and Matrics Cognitive Consensus Battery.

Results: Participants had a mean age of 40.2 years, 57.3% men and mainly Schizophrenia (71.0%). We found gender differences favour to men in attention (p=0.045), working memory (p=0.013) and reasoning/problem solving (p=0.002) domains. No differences in Social Cognition was founded. Linear regression model shows different participations for different domains, with a predominance of the influence of the Cognitive/Disorganized Wallwork's factor and patient's age. In the subsample of men, the model were quite similar to that of total sample, but the influence of the Disorganized factor decreases and that of age remains. In women subsample, the model had even less influence of Disorganized factor or age. In general, women's models explain less variance.